Kenichi Oishi, M.D., Ph.D.

Assistant Professor
Johns Hopkins University
The Russell H. Morgan
Department of Radiology and Radiological Science
Neuroanatomy section, MR Research Division

A.Positions and Honors.
Positions and Employment
05/97 – 05/99 Resident, Dept. of Internal Medicine, Kobe City General Hospital, Kobe, Japan
06/99 – 05/01 Resident, Dept. of Neurology, National Center of Neurology and Psychiatry, Tokyo, Japan
04/03 – 03/04 Teaching Assistant, Dept. of Clinical Molecular Medicine, Kobe University, Kobe, Japan
04/04 – 03/05 Research Assistant, Dept. of Clinical Molecular Medicine, Kobe University, Kobe, Japan
04/05 – 05/05 Neurologist, Div. of Neurology, Kobe University Hospital, Kobe, Japan
06/05 – 09/06 Assistant Professor of Neurology, Kobe University Hospital, Kobe, Japan
02/08 – 06/09 Research Associate, Dept. of Radiology, Johns Hopkins University, MD, U.S.A
07/09 – present Assistant Professor of Radiology, Johns Hopkins University, MD, U.S.A
Other Experience and Professional Memberships
1997- Member, Japanese Society of Internal Medicine
1999- Member, Japanese Society of Neurology
2001- Member, Japanese Society of Stroke 2001- Member, Japanese Society of Neuropsychiatry
2001- Member, Japanese Society of Clinical Neurophysiology
2002- Fellow, Japanese Society of Neurologyv 2005-2006 Hospital Brain Death Advisory Committee, Kobe University Hospital
2005-2006 Resident Training Committee, Kobe University Hospital
2005-2006 Hospital Risk Manager, Kobe University Hospital
2006- Fellow, Japanese Society of Internal Medicine
2010- Member, American Academy of Neurology
Member, International Society of Magnetic Resonance in Medicine
Honors
2004 Travel award for graduate students, Kobe University Graduate School of Medicine
2009 Johns Hopkins University ADRC Pilot Project Award

B. Selected peer-reviewed publications (1-36)

1. Yoshida S, Hayakawa K, Oishi K, Mori S, Kanda T, Yamori Y, Yoshida N, Hirota H, Iwami M, Okano S, Matsushita H. Athetotic and Spastic Cerebral Palsy: Anatomic Characterization Based on Diffusion-Tensor Imaging. Radiology 2011.

2. Oishi K, Mori S, Donohue PK, Ernst T, Anderson L, Buchthal S, Faria A, Jiang H, Li X, Miller MI, van Zijl PC, Chang L. Multi-contrast human neonatal brain atlas: application to normal neonate development analysis. NeuroImage 2011;56(1):8-20.

3. Oishi K, Huang H, Yoshioka T, Ying SH, Zee DS, Zilles K, Amunts K, Woods R, Toga AW, Pike GB, Rosa-Neto P, Evans AC, van Zijl PCM, Mazziotta JC, Mori S. Superficially Located White Matter Structures Commonly Seen in the Human and the Macaque Brain with Diffusion Tensor Imaging. Brain Connectivity 2011;1.

4. Faria AV, Hoon A, Stashinko E, Li X, Jiang H, Mashayekh A, Akhter K, Hsu J, Oishi K, Zhang J, Miller MI, van Zijl PC, Mori S. Quantitative analysis of brain pathology based on MRI and brain atlases--applications for cerebral palsy. NeuroImage 2011;54(3):1854-1861.

5. Zhang Y, Zhang J, Oishi K, Faria AV, Jiang H, Li X, Akhter K, Rosa-Neto P, Pike GB, Evans A, Toga AW, Woods R, Mazziotta JC, Miller MI, van Zijl PC, Mori S. Atlas-guided tract reconstruction for automated and comprehensive examination of the white matter anatomy. NeuroImage 2010;52(4):1289-1301.

6. Qiu A, Oishi K, Miller MI, Lyketsos CG, Mori S, Albert M. Surface-based analysis on shape and fractional anisotropy of white matter tracts in Alzheimer's disease. PloS one 2010;5(3):e9811.

7. Faria AV, Zhang J, Oishi K, Li X, Jiang H, Akhter K, Hermoye L, Lee SK, Hoon A, Stashinko E, Miller MI, van Zijl PC, Mori S. Atlas-based analysis of neurodevelopment from infancy to adulthood using diffusion tensor imaging and applications for automated abnormality detection. NeuroImage 2010.

8. Faria AV, Oishi K, Mori S. Study of white matter anatomy and 3D tract reconstruction by diffusion tensor imaging. International Journal of Imaging Systems and Technology 2010;20(1):51-56.

9. Oishi K, Konishi J, Mori S, Ishihara H, Kawamitsu H, Fujii M, Kanda F. Reduced fractional anisotropy in early-stage cerebellar variant of multiple system atrophy. Journal of Neuroimaging 2009;19(2):127-131.

10. Oishi K, Faria A, Jiang H, Li X, Akhter K, Zhang J, Hsu JT, Miller MI, van Zijl PCM, Albert M, Lyketsos CG, Woods R, Toga AW, Pike GB, Rosa-Neto P, Evans A, Mazziotta J, Mori S. Atlas-based whole brain white matter analysis using large deformation diffeomorphic metric mapping: Application to normal elderly and Alzheimer's disease participants. NeuroImage 2009;46(2):486-499.

11. Mori S, Oishi K, Faria AV. White matter atlases based on diffusion tensor imaging. Current Opinion in Neurology 2009;22(4):362-369.

12. Hua K, Oishi K, Zhang J, Wakana S, Yoshioka T, Zhang W, Akhter KD, Li X, Huang H, Jiang H, Van Zijl P, Mori S. Mapping of functional areas in the human cortex based on connectivity through association fibers. Cerebral Cortex 2009;19(8):1889-1895.

13. Fatemi SH, Folsom TD, Reutiman TJ, Huang H, Oishi K, Mori S. Prenatal viral infection of mice at E16 causes changes in gene expression in hippocampi of the offspring. European Neuropsychopharmacology 2009;19(9):648-653.

14. Fatemi SH, Folsom TD, Reutiman TJ, Abu-Odeh D, Mori S, Huang H, Oishi K. Abnormal expression of myelination genes and alterations in white matter fractional anisotropy following prenatal viral influenza infection at E16 in mice. Schizophrenia Research 2009;112(1-3):46-53.

15. Ceritoglu C, Oishi K, Li X, Chou MC, Younes L, Albert M, Lyketsos C, van Zijl PCM, Miller MI, Mori S. Multi-contrast large deformation diffeomorphic metric mapping for diffusion tensor imaging. NeuroImage 2009;47(2):618-627.

16. Oishi K, Zilles K, Amunts K, Faria A, Jiang H, Li X, Akhter K, Hua K, Woods R, Toga AW, Pike GB, Rosa-Neto P, Evans A, Zhang J, Huang H, Miller MI, van Zijl PCM, Mazziotta J, Mori S. Human brain white matter atlas: Identification and assignment of common anatomical structures in superficial white matter. NeuroImage 2008;43(3):447-457.

17. Mori S, Oishi K, Jiang H, Jiang L, Li X, Akhter K, Hua K, Faria AV, Mahmood A, Woods R, Toga AW, Pike GB, Neto PR, Evans A, Zhang J, Huang H, Miller MI, van Zijl P, Mazziotta J. Stereotaxic white matter atlas based on diffusion tensor imaging in an ICBM template. NeuroImage 2008;40(2):570-582.

18. Kobessho H, Oishi K, Hamaguchi H, Kanda F. Elevation of cerebrospinal fluid protein in patients with diabetes mellitus is associated with duration of diabetes. European Neurology 2008;60(3):132-136.

19. Kanda F, Oishi K, Sekiguchi K, Kuga A, Kobessho H, Shirafuji T, Higuchi M, Ishihara H. Characteristics of depression in Parkinson's disease: Evaluating with Zung's Self-Rating Depression Scale. Parkinsonism and Related Disorders 2008;14(1):19-23.

20. Fatemi SH, Reutiman TJ, Folsom TD, Huang H, Oishi K, Mori S, Smee DF, Pearce DA, Winter C, Sohr R, Juckel G. Maternal infection leads to abnormal gene regulation and brain atrophy in mouse offspring: Implications for genesis of neurodevelopmental disorders. Schizophrenia Research 2008;99(1-3):56-70.

21. Kuga A, Oishi K, Ishida H, Kanda F. A case of orbital apex syndrome caused by localized invasive aspergillosis successfully treated with voriconazole. Clinical Neurology 2007;47(5):207-210.

22. Hikida T, Jaaro-Peled H, Seshadri S, Oishi K, Hookway C, Kong S, Wu D, Xue R, Andrad M, Tankou S, Mori S, Gallagher M, Ishizuka K, Pletnikov M, Kida S, Sawa A. Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans. Proceedings of the National Academy of Sciences of the United States of America 2007;104(36):14501-14506.

23. Kobessho H, Fukunaga A, Mitsui S, Sekiguchi K, Oishi K, Ishihara H, Kanda F. Adult onset Langerhans cell histiocytosis with progressive cerebellar ataxia and spastic paraparesis. Clinical Neurology 2006;46(10):725-728.

24. Kanda F, Sekiguchi K, Oishi K, Hamaguchi H, Mitsui S, Kobessho H, Higuchi M, Shirafuji T, Ishihara H. Intermittent intravenous immunoglobulin infusion prevented relapses in patients with remission-exacerbation type chronic inflammatory demyelinating polyradiculoneuropathy. Clinical Neurology 2006;46(3):236-238.

25. Oishi K, Toma K, Bagarinao ET, Matsuo K, Nakai T, Chihara K, Fukuyama H. Activation of the precuneus is related to reduced reaction time in serial reaction time tasks. Neuroscience Research 2005;52(1):37-45.

26. Nakai T, Matsuo K, Ohgami Y, Oishi K, Kato C. An fMRI study of temporal sequencing of motor regulation guided by an auditory cue - A comparison with visual guidance. Cognitive Processing 2005;6(2):128-135.

27. Sekiguchi K, Kanda F, Oishi K, Hamaguchi H, Nakazawa K, Maeda N, Ishihara H, Chihara K. HLA typing in focal myositis. Journal of the Neurological Sciences 2004;227(1):21-25.

28. Oishi K, Ogawa M, Oya Y, Kawai M. Whole-brain voxel-based correlation analysis between regional cerebral blood flow and intelligence quotient score in Parkinson's disease. European Neurology 2004;52(3):151-155.

29. Al Naggar EA, Kanda F, Okuda S, Maeda N, Nakazawa KI, Oishi K, Sekiguchi K, Ishihara H, Chihara K. Focal myositis in monozygotic twins. Internal Medicine 2004;43(7):599-601.v

30. Sekiguchi K, Oishi K, Hamaguchi H, Maeda N, Nishimoto K, Ishihara H, Kanda F, Chihara K. Acute hemorrhagic encephalitis by varicella-zoster virus in a patient with SLE. [Zasshi] Journal Nihon Naika Gakkai 2003;92(7):1328-1330.

31. Oishi K, Yoshioka M, Ozawa R, Yamamoto T, Oya Y, Ogawa M, Kawai M. Dichloroacetate treatment for adult patients with mitochondrial disease. Clinical Neurology 2003;43(4):154-161.

32. Oishi K, Toma K, Matsuo K, Nakai T, Chihara K, Fukuyama H. Cortical motor areas in plantar response: An event-related functional magnetic resonance imaging study in normal subjects. Neuroscience Letters 2003;345(1):17-20.

33. Yamamoto T, Oishi K, Oya Y, Ogawa M, Kawai M. Compulsive repetition of movements in a case of progressive supranuclear palsy. Clinical Neurology 2002;42(10):925-929.

34. Oishi K, Oya Y, Yamamoto T, Shigeto H, Ogawa M, Kawai M. Quantitative evaluation of the effect of 3,4-diaminopyridine in a patient with Lambert-Eaton myasthenic syndrome using dynamic dynamometry. Clinical Neurology 2001;41(7):515-518.

35. Oishi K, Shigeto H, Maruyama K, Oya Y, Ogawa M, Nonaka I, Kawai M. Overloading to neck extensor muscles is an aggravating factor to induce further neck drop in isolated neck extensor myopathy (Katz). A case report. Clinical Neurology 2000;40(9):933-936.

36. Oishi KI, Sugiura R, Shuntoh H, Kuno T. Cloning and characterization of hsc1+, a heat shock cognate gene of the fission yeast Schizosaccharomyces pombe. Gene 1996;181(1-2):45-49.

Book

1. Oishi K, Faria A, Van Zijl P, Mori S. MRI atlas of human white matter: Elsevier; 2010.
Book chapter

1. Oishi K, Mielke MM, Albert M, Lyketsos CG, Mori S. DTI analyses and clinical applications in Alzheimer’s Disease. Handbook of Alzheimer’s Disease Volume 2, Imaging the Alzheimer’s Disease Brain. Amsterdam, The Netherlands: IOS press; 2011.

Patents

1. Automated image analysis for magnetic resonance imaging, International application # PCT/US09/32866, Mori S., Miller M. I., Zhang, J., Oishi, K.

C. Research Support

Active Research Support:
R21 AG033774-01 (P.I. Kenichi Oishi) 04/01/09 – 03/31/11
National Institute of Health Longitudinal and Cross-sectional White Matter Analysis of Alzheimer's Disease Role : P.I.

RO1 AG20012 (P.I. Susumu Mori) 7/1/07 – 6/31/12  National Institute of Health / National Institute of Aging Human White Matter Tract Maps by Diffusion MRI

U01AG033655 (P.I. Marilyn Albert) 04/01/09-03/31/14 NIH/NIA Biomarkers of Cognitive Decline Among Normal Individuals: The BIOCARD cohort

RO1 NS047691 (PI: Argye Hillis) 7/1/09-06/30/14 NIH/NINDS Neural Basis of Empathy and Prosody This study is aimed at identifying the neural correlates of impairments of empathy and prosody in acute ischemic stroke and later recovery, through longitudinal MRI diffusion and perfusion imaging and cognitive testing at the same time periods.

Completed Research Support: High Q (P.I. Sarah Reading) 04/01/2008 – 03/31/2010 High Q Foundation To study frontal white matter in pre-manifest Huntington’s disease using MRI.

Foreign study grants, Clinical medicine – 2 (P.I. Kenichi Oishi) 02/01/2007 – 01/31/2008 The Kanae Foundation for the Promotion of Medical Science Study of the pathogenesis of animal model neurodegenerative disease using MRI.